연구성과 홍보

Int J Environ Health Res. 2025 Mar;35(3):693-705.

Title : Association between exposure to specific PM2.5 constituents and environment, lifestyle, and clinical parameters in patients with COPD

Authors : Jieun Kang1, Hajeong Kim2, Ji Ye Jung3, Jin-Young Huh4, Hyun Woo Ji5, Seon-Jin Lee6, Hwan-Cheol Kim7, Sei Won Lee8*

Affiliations :

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Republic of Korea.

2Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Republic of Korea.

3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

4Division of Pulmonary, Allergy and Critical Care Medicine, Chung-Ang University Gwangmyeong Medical Center, Gwangmyeong, Korea.

5Division of Pulmonology, Department of Internal Medicine, National Health Insurance Service Ilsan Hospital, Goyang, Republic of Korea.

6Environmental Disease Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.

7Department of Occupational and Environmental Medicine, Inha University Hospital, Inha University College of Medicine, Incheon, Republic of Korea.

8Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

DOI: 10.1080/09603123.2024.2368724.

Abstract :

This study investigated the correlation between the individual chemical constituents of particulate matter 2.5 μm (PM_2.5) and respiratory parameters as well as the living environment and daily behaviors in patients with chronic obstructive pulmonary disease (COPD). Data were obtained from prospective COPD panel conducted in South Korea. Following collection via a microPEM, 18 metallic elements were determined using energy-dispersive X-ray fluorescence spectroscopy. All participants completed detailed questionnaires on living environments and lifestyle practices. Eighty-nine stable COPD patients (mean age 68.1 years; 94.4% male) were analyzed. Several constituents (titanium, aluminum, bromine, and silicone) were significantly associated with respiratory outcomes. Copper and manganese concentrations were significantly associated with the living environment. Increased ventilation time and air purifier operation were associated with lower concentrations of copper, silicone, barium, and titanium. These findings suggest varying relationships between PM_2.5 constituents and clinical parameters in COPD patients, providing a basis for personalized interventions and future research.