연구성과 홍보

Respir Res. 2024 Nov 26;25(1):414.

Title : Association between metabolic syndrome and chronic obstructive pulmonary disease development in young individuals: a nationwide cohort study

Authors : Ock-Hwa Kim1, Kyu Na Lee2, Kyungdo Han3, In Young Cho4, Dong Wook Shin5,6*, Sei Won Lee7*

Affiliations :

1Division of Pulmonology and Allergy, Department of Internal Medicine, Chungnam National University, Chungnam National University Sejong Hospital, Sejong, Republic of Korea.

2Department of Biomedicine and Health Science, The Catholic University of Korea, Seoul, Republic of Korea.

3Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea.

4Department of Family Medicine & Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

5Department of Family Medicine & Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. dwshin.md@gmail.com.

6Department of Clinical Research Design and Evaluation, Department of Digital Health, Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, South Korea.

7Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea.

DOI: 10.1186/s12931-024-03038-z.

Abstract :

Background: The association between metabolic syndrome (MetS) and chronic obstructive pulmonary disease (COPD) has not been studied well, particularly in young individuals. We investigated the risk of COPD development in young individuals based on MetS and its components.

Methods: We used the Korean National Health Information Database to identify 6,891,400 individuals aged 20-39 years who participated in the national health check-up service between 2009 and 2012. Then, we identified individuals with MetS and investigated COPD development based on health insurance claims. Cox proportional hazard regression models were used to calculate the adjusted hazard ratio (aHR) for the risk of COPD development.

Results: During a mean follow-up period of 8.35 years, 13,784 individuals were newly diagnosed with COPD. MetS was associated with an increased risk of COPD (aHR, 1.18; 95% confidence interval [CI], 1.11-1.24). Among the MetS components, except for hyperglycemia, abdominal obesity (aHR, 1.27; 95% CI, 1.19-1.34), hypertension (aHR, 1.05; 95% CI, 1.01-1.10), hypertriglyceridemia (aHR, 1.11; 95% CI, 1.07-1.16), and low high-density lipoprotein cholesterol levels (aHR, 1.16; 95% CI, 1.11-1.22) were significantly associated with COPD development. A higher number of MetS components correlated with an increased risk of COPD development, with the highest risk observed when all five MetS components were present (aHR, 1.55; 95% CI, 1.28-1.87).

Conclusion: MetS was associated with COPD development in young individuals. The risk of COPD development increased along with the increasing number of MetS components. These findings suggest that careful monitoring for COPD development is necessary in young individuals with MetS, especially those with multiple components of MetS.