연구성과 홍보

J Invest Dermatol. 2024 Apr 20:S0022-202X(24)00257-4.

Title : Childhood Obesity, Weight Change, and Pediatric Immune-Mediated Skin Diseases

Authors : Seong Rae Kim1, Seong-Joon Koh2*, Hyunsun Park3*

Affiliations :

1Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea.

2Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Intestinal Mucosa and Skin Immunology, Seoul, Republic of Korea.

3Department of Dermatology, Seoul National University College of Medicine, Seoul, Republic of Korea; Laboratory of Intestinal Mucosa and Skin Immunology, Seoul, Republic of Korea; Department of Dermatology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea.

DOI: 10.1016/j.jid.2024.01.037.

Abstract :

Whether childhood obesity or weight gain leads to the development of pediatric immune-mediated skin diseases remains unclear. We aimed to determine the associations between body mass index or body mass index changes and the development of 3 main immune-mediated skin diseases-alopecia areata, atopic dermatitis (AD), and psoriasis-by analyzing a longitudinal cohort of 2,161,900 Korean children from 2009 to 2020. The findings indicated that children who were obese had a higher risk of pediatric immune-mediated skin diseases than those with normal weight (P for trend < .01). An increase in body mass index was associated with a higher risk of AD, whereas a decrease in body mass index was correlated with a reduced risk of AD. Children who gained weight, transitioning from normal to overweight, exhibited a higher AD risk than those who maintained a normal weight (adjusted hazard ratio = 1.15, 95% confidence interval = 1.11-1.20). However, those who shifted from being overweight to achieving a normal weight (adjusted hazard ratio = 0.87, 95% confidence interval = 0.81-0.94) had a lower AD risk than children who were overweight who maintained their weight. In summary, early childhood obesity may increase the risk of pediatric immune-mediated skin diseases. Weight gain may increase AD risk, whereas weight loss may lower the risk.